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Synlett 1992; 1992(1): 53-54
DOI: 10.1055/s-1992-21263
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Syntheses of Amine Building Blocks for Dendritic Macromolecule Construction1

George R. Newkome* , Xiaofeng Lin, James K. Young
  • *Center for Molecular Design and Recognition, Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA
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Publication Date:
18 September 2002 (online)

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Facile, selective O-addition of tris(hydroxymethyl)-aminomethane (1; 2-amino-2-hydroxymethylpropane-1,3-diol) to acrylonitrile afforded after ethanolysis amine building block 3 [tris(2-ethoxycarbonylethoxymethyl)aminomethane] suitable for 4-directional dendritic construction. Subsequent incorporation of an arylamino moiety afforded a useful [1 → 6]-cascade molecule.